pugnacious tough hard-bitten

stimulant soporific Fergon virility drug street drug myotic water pill Trental miotic drug mind-altering drug Lorfan pharmacopoeia abortifacient proprietary drug pentoxifylline anti-impotence drug botanical anaesthetic consciousness-altering drug hypnotic generic drug medicinal drug controlled substance diuretic miotic excitant medicament agent medication agonist brand-name drug levallorphan medicine psychotropic agent psychoactive drug antisyphilitic dilator anaesthetic agent antagonist myotic drug anti-TNF compound mydriatic drug relaxant appetite suppressant drug of abuse mydriatic narcotic abortion-inducing drug suppressant stimulant drug anesthetic anesthetic agent intoxicant aborticide diuretic drug synergist psychoactive substance fertility drug arsenical Feosol

serious tough thorny problematical demanding rugged difficult touchy challenging knotty rocky embarrassing tricky arduous difficultness hard-fought problematic vexed nasty trying unenviable awkward troublesome fractious baffling effortful elusive sticky herculean tight difficulty tall ticklish ambitious catchy delicate rough

unmerciful tough scheming shrewd insensitive conniving merciless hardened calculating hard-boiled case-hardened difficult calculative steely

hardened hornlike solid adamantine unyielding tumid erect stony stonelike corneous set semihard granitic rocklike woody al dente horny petrous granitelike steely firm hardness

severe strong knockout

heavy effortful punishing operose arduous laborious backbreaking gruelling toilsome grueling

firmly

o.d. anaesthetise dose medicate dope medicine anesthetize narcotise dope up put out anesthetise narcotize poison overdose anaesthetize put under

severely