noun. a medicine for external application that produces redness of the skin.
1. Adjective Isopropyl alcohol is said to have a rubefacient effect on the skin, meaning it cools and soothes tired, weathered skin. 2. Noun, singular or mass For personal applications, synthetic camphor is found in such pharmaceuticals as antipruritics and anti-infectives as well as in rubefacient medications that relieve pain and itching.