noun. a hybrid produced by crossing parents that are homozygous except for a single gene locus that has two alleles (as in Mendel's experiments with garden peas).
Example sentences of the word monohybrid
A monohybrid genetic cross centers around only one trait that is different in the two parent plants.
2. Noun, singular or mass
In this particular monohybrid cross, there is a fifty-fifty chance that any given child will have a widow's peak.